After hearing about Neo4j at RubyManor Robert Rees tried using it from Groovy and experienced some problems getting started. This was discussed on the Neo4j mailinglist as well. Topics mentioned are the packaging of Neo4j in multiple jar files, using transactions, the Neo4j API and the need for explicit shutdown.
Reading Emil's QCon slides Guillame Laforge, project lead of the Groovy language, got interested in how to bring in some Groovyisms to Neo4j. This topic got discussed on the mailing list, with input from the people working on bindings for Python and Ruby. One more topic that surfaced was to use Neo4j as a Django backend.